Effect of immunonutrition on serum levels of C-reactive protein and lymphocytes in patients with COVID-19: a randomized, controlled, double-blind clinical trial.

INTRODUCTION: Introduction: patients with COVID-19 undergo changes in leukocyte count, respiratory disorders, and an increase in inflammatory substances. To improve the inflammatory condition, some nutrients can be used, including arginine, omega-3 fatty acids and nucleotides. This study aims to evaluate how oral immunonutrient supplements affects serum C-reactive protein (CRP) levels and lymphocyte count in patients with COVID-19. Methods: in this double-blind clinical trial, we randomized 43 adult patients with COVID-19 to receive a standard high-protein normocaloric supplement (control) or an immunonutrient-enriched supplement (experiment) for 7 days. The primary outcome was to evaluate changes in total lymphocyte count and serum level of CRP. The assessment of risk and nutritional status of these patients was also performed. Results: forty-three patients with mean age of 41.5 (± 1.8) years were followed up, 39.5 % of them women. The mean body mass index was 27.6 (± 0.8) kg/m² and 58.1 % had low nutritional risk. In the experiment group, there was a CRP reduction of 23.6 (± 7.5) mg/L, while in the control branch the decrease was 14.8 (± 12.1) mg/L (p = 0.002). There was an increase in lymphocytes in the experiment group (+367.5 ± 401.8 cells/mm³) and a reduction in the control group (-282.8 ± 327.8 cells/mm³), although there was no statistical significance (p = 0.369). Relative risk (RR) of treatment in reducing CRP by 30 % or more was 4.45 (p < 0.001; 95 % CI, 1.79-11.07). RR in increasing lymphocyte count by 30 % or more was 1.28 (p = 0.327; 95 % CI, 0.67-2.45). Conclusion: we conclude that immunonutrient supplements seem to reduce CRP levels more than standard high-protein normocaloric supplements.

INTRODUCCIÓN: Introducción: los pacientes con COVID-19 sufren cambios en el recuento de leucocitos, trastornos respiratorios y aumento de sustancias inflamatorias. Para mejorar la condición inflamatoria se pueden usar algunos nutrientes, como la arginina, los ácidos grasos omega-3 y los nucleótidos. Este estudio tiene como objetivo evaluar cómo los suplementos de inmunonutrientes orales afectan a los niveles séricos de proteína C-reactiva (PCR) y al recuento de linfocitos en pacientes con COVID-19. Métodos: en este ensayo clínico doble ciego, aleatorizamos a 43 pacientes adultos con COVID-19 para recibir un suplemento normocalórico estándar alto en proteínas (control) o un suplemento enriquecido con inmunonutrientes (experimento) durante 7 días. El resultado primario fue evaluar los cambios en el recuento total de linfocitos y el nivel sérico de PCR. También se realizó la evaluación del riesgo y el estado nutricional de estos pacientes. Resultados: cuarenta y tres pacientes con edad media de 41,5 (± 1,8) años fueron seguidos, el 39,5 % de ellos mujeres. El índice de masa corporal medio fue de 27,6 (± 0,8) kg/m² y el 58,1 % tenían bajo riesgo nutricional. En el grupo experimental hubo una reducción de la PCR de 23,6 (± 7,5) mg/L, mientras que en la rama de control la disminución fue de 14,8 (± 12,1) mg/L (p = 0,002). Hubo un aumento de linfocitos en el grupo experimental (+367,5 ± 401,8 células/mm³) y una reducción en el grupo de control (-282,8 ± 327,8 células/mm³), aunque no hubo significación estadística (p = 0,369). El riesgo relativo (RR) del tratamiento para reducir la PCR en un 30 % o más fue de 4,45 (p < 0,001; IC 95 %: 1,79-11,07). El RR en el aumento del recuento de linfocitos en un 30 % o más fue de 1,28 (p = 0,327; IC 95 %: 0,67-2,45). Conclusión: se concluye que los suplementos de inmunonutrientes parecen reducir los niveles de PCR más que los suplementos normocalóricos estándar altos en proteína.

The Prevalence of Abdominal Adiposity among Primary Health Care Physicians in Bahia, Brazil: An Epidemiological Study.

BACKGROUND: Labor activities are demanding for workers and can induce occupational stress. Primary health care (PHC) workers have faced problems that can lead to the development of stress and abdominal obesity. The aim of this study was to estimate the prevalence of abdominal adiposity among primary health care physicians in the metropolitan mesoregion of Salvador, Bahia. METHODS: This is a cross-sectional study conducted with physicians from the family health units (FHUs) of the metropolitan mesoregion of Salvador, Bahia, Brazil. The number of FHUs corresponded to 41 teams (52 physicians). Anamnesis was performed and a questionnaire was applied. The clinical examination consisted of measuring waist circumference (WC), blood pressure levels (BP), and body mass index (BMI), as well as examining for acanthosis nigricans. Blood samples were collected for biochemical dosages. The data obtained were analyzed by SPSS version 22.0. RESULTS: The sample included 41 physicians (response rate: 78.8%), of which 18 were women (44.0%). The percentage of overweight participants represented by BMI was 31.7%. The hypertriglyceridemia prevalence was 29.2%. HDL-c was low in 48.7% of the participants. The waist circumference measurement revealed a prevalence of abdominal adiposity of 38.8% (women) and 34.8% (men). CONCLUSIONS: Medical professionals in PHC are more susceptible to having higher abdominal adiposity, especially female physicians.

Burnout syndrome and metabolic syndrome: a cross-sectional population-based study.

In the population of Primary Health Care Nursing (PHC) professionals, the association between Burnout Syndrome (BS) and Metabolic Syndrome (MS) has not been investigated. The objective was to evaluate the association between BS and MS among PHC Nursing Professionals. A cross-sectional, multicenter, population-based study was conducted in the state of Bahia, Brazil, with 1,125 professionals. The prevalence of BS and MS corresponded to 18.3% and 24.4%, respectively. The prevalence in women of BS was 16.4% and of MS 23.7%, in men 31.6% for BS and 29.4% for MS. Men with BS are 3.23 times more likely to develop MS, and women 1.48 times more. BS was associated between men and women and exhibited a good discriminatory predictive power.

Prevalence and Factors Associated with Burnout Syndrome among Primary Health Care Nursing Professionals: A Cross-Sectional Study.

The objective of the study was to evaluate the prevalence and factors associated with Burnout Syndrome (BS) in Primary Health Care (PHC) nursing professionals from the state of Bahia, Brazil. A multicentre, cross-sectional population-based study was conducted in a cluster sample among 1125 PHC Nursing professionals during the years 2017 and 2018. We used a questionnaire that included sociodemographic, labor and lifestyle variables and the Maslach Burnout Inventory scale to identify BS. The associations were evaluated using a robust Poisson regression with the hierarchical selection of the independent variables. The prevalence of BS was 18.3% and the associated factors were ethnicity (prevalence ratio (PR) = 0.62, confidence interval (CI) 95% = 0.47-0.83), residence (PR = 2.35, CI 95% = 1.79-3.09), economic situation (PR = 1.40, CI 95% = 1.06-1.86), satisfaction with current occupation (PR = 1.75, CI 95% = 1.31-2.33), (PR = 1.60, CI 95% = 1.23-2.08), rest (PR = 1.83, 95% CI = 1.41-2.37), technical resources and equipment (PR = 1.37, CI 95% = 1.06-1.77), night shift (PR = 1.49, CI 95% = 1.14-1.96), physical activity practice (PR = 1.72; CI 95% = 1.28-2.31), smoking (PR = 1.82, CI 95% = 1.35-2.45), and satisfaction with physical form (PR = 1.34, CI 95% = 1.01-179). Strategies are needed to prevent BS, with an emphasis on implementing worker health programs in the context of PHC.

Síndrome de Burnout em residentes multiprofissionais em saúde / Burnout syndrome in multi-professional healthcare residents / Síndrome de Burnout en residentes multiprofesionales en salud

Objetivo: estimar a prevalência da Síndrome de Burnout e identificar o perfil sociodemográfico, laboral, estilo de vida e saúde de residentes multiprofissionais de saúde de uma Universidade pública da Bahia, Brasil. Metodologia: estudo transversal, descritivo, realizado com 63 residentes. Utilizou-se o Maslach Burnout Inventory e um questionário contendo questões sociodemográficas, laborais, estilo de vida e saúde. Resultados: ao analisar as dimensões da síndrome, 82,5% apresentaram nível alto de exaustão emocional; 55,5% nível moderado de despersonalização e 88,8% nível alto de reduzida realização profissional. Destaca-se a maior ocorrência do Burnout em enfermeiros (50%), profissionais atuantes no âmbito hospitalar (71,4%) e em recém-formados (média 2,1 anos). 60,3% dos residentes consideraram não ter uma alimentação saudável e 29,5% apresentaram excesso de peso. Conclusão: os resultados apontam uma prevalência significativa de síndrome de burnout, sendo encontradas altas alterações nas três dimensões da síndrome em 22,2% dos residentes.

Objective: to estimate the prevalence of Burnout Syndrome, and identify the sociodemographic, occupational, lifestyle, and health profile of multi-professional healthcare residents at a public university in Bahia, Brazil. Methods: a descriptive, crosssectional study was conducted with 63 residents, using the Maslach Burnout Inventory and a questionnaire on sociodemographic, labor, lifestyle, and health issues. Results: on examining the dimensions of the syndrome, 82.5% were found to present high levels of emotional exhaustion; 55.5%, moderate levels of depersonalization; and 88.8%, high levels of diminished professional fulfilment. Burnout occurred most often in nurses (50%), professionals working in hospitals (71.4%) and recent graduates (mean 2.1 years), while 60.3% of the residents regarded their diet at unhealthy, and 29.5% were overweight. Conclusion: the results indicate a significant prevalence of Burnout Syndrome, and marked changes in the three dimensions of the syndrome were found in 22.2% of the residents.

Objetivo: estimar la prevalencia del Síndrome de Burnout e identificar el perfil sociodemográfico, laboral, estilo de vida y salud de residentes multiprofesionales de salud de una universidad pública de Bahía, Brasil. Método: estudio transversal, descriptivo, realizado junto a 63 residentes. Se utilizó el Maslach Burnout Inventory y un cuestionario que contenía cuestiones sociodemográficas, laborales, estilo de vida y salud. Resultados: al analizar las dimensiones del síndrome, el 82,5% presentó un alto nivel de agotamiento emocional; 55,5% nivel moderado de despersonalización y 88,8% nivel alto de reducida realización profesional. Se destaca la mayor ocurrencia de Burnout en enfermeros (50%), profesionales actuantes en el ámbito hospitalario (71,4%) y recién graduados (promedio 2,1 años). El 60,3% de los residentes consideró no tener una alimentación sana y el 29,5% presentó un exceso de peso. Conclusión: los resultados apuntan a una prevalencia significativa de síndrome de Burnout y se encontraron grandes alteraciones en las tres dimensiones del síndrome en el 22,2% de los residentes.

Prevalência da Síndrome de Burnout em profissionais de enfermagem da atenção básica à saúde / Prevalencia del Síndrome de Burnout en profesionales de enfermería de atención de la salud básica / Prevalence of Burnout Syndrome in nursing professionals of basic health care

Objective: to estimate the prevalence of Burnout Syndrome among the Primary Health Care nurses in a city of Bahia Southwest. Methods: Cross-sectional study, conducted with 60 nursing professionals of primary care. We used a sociodemographic and occupational questionnaire, and the Maslach Burnout Inventory. Data were tabulated using SPSS, version 22.0, and analyzed using descriptive statistics. Results: The prevalence of burnout syndrome was 58.3% according to the criteria of Grunfeld et al, and 16.7% according to Ramirez et al., they have found high levels in the dimension depersonalization (48.3%) and low job satisfaction (56.6%). The prevalence of burnout syndrome in the study population was high, as was the high rate predisposition to develop this syndrome. Conclusions: The study pointed out the need to implement preventive and interventional measures to ensure a beneficial and promising health work environment.

Objetivo: estimar a prevalência da Síndrome de Burnout entre profissionais de enfermagem da Atenção Básica à Saúde de um município do sudoeste baiano. Método: Estudo de corte transversal, realizado com 60 profissionais de enfermagem da Atenção Básica. Utilizou-se um questionário sociodemográfico e laboral, e o Maslach Burnout Inventory. Os dados foram tabulados no SPSS versão 22.0 e analisados segundo estatística descritiva. Resultados: A prevalência de Síndrome de Burnout foi de 58,3%, de acordo os critérios de Grunfeld et al., e de 16,7% segundo Ramirez et al. Encontraram-se altos níveis na dimensão despersonalização (48,3%) e baixa realização profissional (56,6%). A prevalência da Síndrome de Burnout na população estudada foi alta, assim como foi alto o índice de predisposição para desenvolver esta síndrome. Conclusões: O estudo apontou a necessidade de implementação de medidas preventivas e interventivas para garantir um ambiente de trabalho benéfico e promissor de saúde.

Objetivo: estimar la prevalencia del Síndrome de Burnout entre las enfermeras de Atención Primaria de la Salud en la ciudad de Bahía Suroeste. Métodos: Estudio transversal, realizado con 60 profesionales de atención primaria. Se utilizó un cuestionario sociodemográfico ocupacional y el Maslach Burnout Inventory. Los datos fueron tabulados mediante el programa SPSS, versión 22.0, y analizados mediante estadística descriptiva. Resultados: La prevalencia del Síndrome de Burnout fue del 58,3%, según los criterios de Grunfeld et al., y el 16,7%, de acuerdo a los altos niveles de Ramírez et al. Ellos han encontrado en la despersonalización dimensión (48,3%) y la satisfacción laboral bajo (56,6%). La prevalencia del síndrome en la población de estudio fue alta, al igual que la predisposición tasa alta de desarrollar este síndrome. Conclusiones: El estudio señala la necesidad de implementar medidas de prevención y de intervención para garantizar un ambiente de trabajo de salud beneficioso prometedor.

Burnout syndrome and abdominal adiposity among primary health care nursing professionals

Background: Accumulation of abdominal adiposity (AA) constitutes a risk factor for heart and coronary diseases and for metabolic complications. Research suggests that stress is related to adipogenesis. The burnout syndrome (BS) is linked to stress due to the chronicity of work stress. The objective of this study is to estimate the association between BS and AA in Primary Health Care (PHC) nursing practitioners. Methods: This is confirmatory cross-sectional study with 189 workers from nine municipalities in Bahia, Brazil. The dependent variable was AA, measured by waist circumference. The independent variable was the BS, diagnosed by the Maslach Burnout Inventory (MBI). Sociodemographic and job characteristics, lifestyle, and human biology were taken as covariates and were evaluated as modifiers or confounders by the homogeneity tests and by comparison with the adjusted Mantel-Haenszel test, respectively. Logistic regression was employed to evaluate the association between BS and AA, adjusted for covariates. The adequacy of the final regression model was evaluated by the model's goodness of fit test and the area under the ROC curve. Results: BS prevalence was 10.6% and AA 54%. The variables age, education, hypertension, diabetes, working time, and high emotional exhaustion were associated with AA. An association was found between BS and AA (1.63 adjusted prevalence ratios; 95% CI, 1.29 to 2.06) even after age and working time adjustment. Conclusion: The results suggest an association between BS and AA in the analyzed professionals. A significant prevalence of burnout and AA is highlighted. (AU)